Mayo are working with the HSE over a number of Covid-19 related queries among the panel which could have an impact on the game with Leitrim.
As things stand, Mayo are continuing their preparations for Sunday's Connacht senior football championship semi-final in Castlebar.
The county are following HSE guidelines.
Midwest Radio are reporting that a number of players are isolating.
James Horan's side won their opening Connacht match against Sligo by 3-23 to 12 points.
Last year, Sligo had to forfeit their Connacht game against Galway and played no part in the Championship after a raft of positive coronoavirus tests within their panel.