Sheffield United duo David McGoldrick and Callum Robinson will miss the Republic of Ireland's friendly against Bulgaria next week.
The sides are set to meet in the Aviva Stadium at 7.45 on Tuesday 10 September.
The FAI have confirmed that McGoldrick has returned to England for further treatment on a shoulder injury that he picked up ahead of Thursday night’s 1-1 draw with Switzerland.
Robinson meanwhile will also report for treatment at Sheffield United; that's after he picked up a hamstring strain which saw him being replaced in the clash.
The remaining 22 players in the squad are now off until lunch-time on Sunday ahead of the Bulgaria fixture.
Those who started against Switzerland took part in a pool recovery session on Friday morning while the rest of the players undertook a training session at Abbotstown.
“Both David and Callum won’t be coming back in when the squad report back to the Castleknock Hotel on Sunday,” Ireland boss Mick McCarthy said whilst confirming he has no plans to call up any additional players to his squad.
“David came into camp with a shoulder injury but was determined to play against Switzerland and what a game he had. He was brilliant from start to finish and capped off a great performance with a first Ireland goal that was no more than he deserved.
“Callum felt his hamstring in the second half of the game so it is best now that he also goes back to Sheffield United for treatment. There are a few other bumps and bruises about the place but we will see how everyone feels after their short break over the weekend and take it from there on Sunday.”
Following next week's friendly, McCarthy's side are away to Georgia and Switzerland next month as they continue their quest to qualify for Euro 2020.