Chelsea have opened up a five-point gap at the top of the Premier League.
Two apiece for Oscar and Diego Costa helped Jose Mourinho's side to a 5-0 win against Swansea.
Southampton regained third spot with a 2-1 win away to Newcastle. It was Eljero Elia with Southampton's goals at St James' Park.
Dwight Gayle also managed a brace at Turf Moor, where Crystal Palace enjoyed a 3-2 win against Burnley.
There was only a single goal at King Power Stadium, where Krkic Bojan secured a win for Stoke.
Second half goals from Marouane Fellaini and James Wilson saw Manchester United overcome QPR, keeping them in the top four for the moment.
Elsewhere, Tottenham enjoyed a 2-1 win against Sunderland, while Liverpool's two goals gave them a win against Aston Villa at Villa Park.
Aston Villa 0 Liverpool 2
(L: Borini 25', Lambert 79')
Burnley 2 Crystal Palace 3
(B: Mee 13', Ings 15' // CP: Gayle 29', 88', Puncheon 48')
Leicester 0 Stoke 1
(S: Bojan 63')
QPR 0 Manchester United 2
(MU: Fellaini 58', Wilson 90+')
Swansea 0 Chelsea 5
(C: Oscar 1', 36', Costa 20', 35', Schurrle 80')
Tottenham 2 Sunderland 1
(T: Vertonghen 3', Eriksen 88' // S: Larsson 30')
Southampton 2 Newcastle 1
(S: Elia 14', 62' // N: Gouffran 29')
Originally posted at 17.23